These results are the first evidence that maternal ENM inhalation impacts the fetal epigenome. Changes in normal physiology were linked with other tissues, including liver and kidneys. The most notable alterations in major biologic systems included immune adaptation and organismal growth.
The results of the sequencing experiments provide initial evidence that significant epigenetic and transcriptomic changes occur in the cardiac tissue of maternal nano-TiO 2 exposed progeny. Ingenuity Pathway Analysis (IPA) was then used to identify pathways most modified by gestational ENM exposure. RNA from fetal hearts was purified and prepared for RNA sequencing and transcriptomic analysis. Following chromatin immunoprecipitation (ChIP), DNA fragments were sequenced. DNA was extracted and immunoprecipitated with modified chromatin marks histone 3 lysine 4 tri-methylation (H3K4me3) and histone 3 lysine 27 tri-methylation (H3K27me3). Pregnant dams were exposed to nano-titanium dioxide (nano-TiO 2) aerosols (10 ± 0.5 mg/m 3) for 7-8 days (calculated, cumulative lung deposition = 217 ± 1 μg) and on GD (gestational day) 20 fetal hearts were isolated. The purpose of these studies was to identify genetic alterations in the F1 generation of Sprague-Dawley rats that result from maternal ENM inhalation during gestation. We, and others, have explored the consequences of ENM inhalation during gestation and identified many cardiovascular and metabolic outcomes in the F1 generation. As the diversity of these exposures continues to increase, the fetal ramifications of maternal exposures have yet to be determined. Cardiovascular dysfunctions have been reported in adult populations after exposure to a variety of ENM. 9SoftwareLatestRelease.DownloadLatestReleaseof TallyERP9Rel5.4.8.The integration of engineered nanomaterials (ENM) is well-established and widespread in clinical, commercial, and domestic applications.
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